MRI-STRUCTURE

Magnetic Resonance Imaging Signal To Recover Unique Cerebral TissUe Response to changEs

While several pathologies can affect the brain over the lifespan, all involving different kind of microstructural changes affecting specific tissue compartments like myelin, axons, glia cells or neurons, our ability to diagnose and monitor disease progression, as well as evaluate the efficacy of new therapies, is limited by the lack of specificity of current non-invasive imaging techniques.

The EU-funded project MRI-STRUCTURE aims at developing an innovative imaging technique, based on magnetic resonance, to look at different cell compartments in the brain, in vivo and non-invasively.

An instrument capable of increasing the specificity of our analysis when looking into the brain is expected to have a tremendous impact on how brain diseases are diagnosed and treated, with a huge benefit for our society.

Selected Publications

2020

R. Garcia-Hernandez, A. Trouve Carpena, M. Drakesmith, K. Koller, D.K. Jones, S Canals, S. De Santis. Mapping Microglia and Astrocytes activation in vivo using Diffusion MRI. BioRxiv: 10.1101/2020.02.07.938910

2019

S. De Santis, P. Bach, L. Pérez-Cervera, A. Cosa-Linan, G. Weil, S. Vollstädt-Klein, D. Hermann, F. Kiefer, P.Kirsch, R. Ciccocioppo, W. H. Sommer, S. Canals. Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence. JAMA Psychiatry 2019;76(7):749-758.

S. De Santis, T. Granberg, R. Ouellette, C.A. Treaba, E. Herranz, Q. Fan, C. Mainero, N. Toschi (2019), Early axonal damage in normal appearing white matter in Multiple Sclerosis: novel insights from multi-shell diffusion MRI. Neuroimage:Clinical 2019, 22:101699

S. De Santis, S. Canals. Non-invasive MRI windows to Neuroinflammation. Neuroscience 2019, 403:1-3

S. De Santis, W.H. Sommer, S. Canals. Detecting Alcohol-induced Brain Damage Non-Invasively Using Diffusion Tensor Imaging. ACS Chemical Neuroscience 2019, 10:4187-4189

2018

S. De Santis, M. Bastiani, A. Droby, P. Kolber, E. Pracht, T. Stoecker, F. Zipp, S. Groppa, A. Roebroeck. Characterizing white matter degeneration in Multiple Sclerosis: the impact of experimental design on advanced diffusion MRI biomarkers. Neuroscience (in press).

Media Appearances

https://neurosciencenews.com/alcohol-brain-damage-10985/?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+neuroscience-rss-feeds-neuroscience-news+%28Neuroscience+News+Updates%29

https://medicalxpress.com/news/2019-04-alcohol-induced-brain-alcohol.html

https://www.inverse.com/article/54579-alcohol-brain-white-matter-damage

http://www.rtve.es/noticias/20190403/dano-cerebral-causado-alcohol-no-se-detiene-dejar-beber/1916280.shtml

https://www.elmundo.es/ciencia-y-salud/salud/2019/04/03/5ca4d6f821efa0b0688b462d.html

https://www.lavanguardia.com/vida/20190403/461447240202/dano-cerebral-alcohol-estudio.html

https://www.abc.es/salud/enfermedades/abci-alcohol-sigue-danando-cerebro-incluso-cuando-dejado-beber-201904031700_noticia.html

https://www.efe.com/efe/espana/efefuturo/resumen-de-la-ciencia-espanola-2019/50000905-4141103

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